A synthetic antibacterial agent of a broad spectrum fluoroquinolone, containing as active substance levofloxacin – laevorotatory isomer of ofloxacin.Levofloxacin blocking gyrase, and crosslinking gives supercoiling breaks, inhibit anavar oxandrolone synthesis, causes profound morphological change in the cytoplasm, the cell wall and membranes. Levofloxacin is active against most strains where to buy aromasin bodybuilding of microorganisms in conditions in vitro and in vivo.
Levofloxacin is rapidly and almost completely absorbed after oral administration. Food intake has little effect on the speed and completeness of removals. Bioavailability of 500 mg oral levofloxacin after is nearly 100%. After administration of a single 500 mg dose of levofloxacin is the maximum concentration of 5.2-6.9 g / ml, time to maximum concentration -. 1,3ch half-life – 8.6 hours.
Relationship to plasma proteins – 30-40%. It penetrates the tissues and organs: lungs, bronchial mucosa, sputum, organs of the urogenital system dynabolon, bone tissue, cerebrospinal fluid, the prostate gland, polymorphonuclear leukocytes, alveolar macrophages.
In the liver, a small part of the oxidized and / or deacetylated. Report from the body mainly by the kidneys by glomerular filtration and tubular secretion. Following anavar oxandrolone oral administration, approximately 87% of the dose is excreted in the urine unchanged within 48 hours, less than 4% in the faeces within 72 hours.
Indications for use:
Infectious-inflammatory diseases, caused by susceptible microorganisms: acute sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia, complicated urinary tract infections (including pyelonephritis), uncomplicated urinary tract infections, prostatitis, infections of skin and soft tissues, septicemia / bacteremia associated sustanon 250 gains with the above readings, intra-abdominal infection.
- hypersensitivity to levofloxacin or other quinolones;
- tendon injury during the earlier treatment of quinolones;
- childhood and adolescence (18 years);
- pregnancy and lactation.
The drug should be used with caution in the elderly, due to the high probability of the presence of a concomitant decrease in renal function british dragon reviews, with a deficit of anavar oxandrolone dehydrogenase.