The absolute bioavailability of amoxicillin is 94%. The absorption is independent of food intake. The maximum plasma concentration observed after 1-2 hours after administration of amoxicillin. After receiving a single dose of 500 / 125mg oxandrolone for sale, the average concentration of amoxicillin (after 8 hours) 0.3 mg / l. Binding to serum proteins is approximately 17-20%.
Amoxicillin crosses the placental barrier and passes into breast milk. Small amounts of Amoxicillin is metabolized in the liver (10% of the administered dose), mainly eliminated via the kidneys and a small amount is excreted in the bile. The of blood serum in patients with normal renal function was approximately 1 hr (0.9-1.2 hours) in patients with a creatinine clearance in the range of 10-30 ml / min is 6 hours, while in the case of anuria ranges between 10 and 15 hours. The drug appears in hemodialysis. Clavulanic acid: The absolute bioavailability of clavulanic acid of approximately 60%. The absorption is independent of food intake. The maximum concentration of clavulanic acid in the blood observed after 1-2 hours after administration. After a single dose of 0.5 g / 125 mg (amoxicillin / clavulanic acid) the mean maximum concentration of clavulanic acid reached 0.08 mg / l after 8 hours. Binding to plasma proteins is 22%. Clavulanic acid crosses the placental barrier. Reliable data on the penetration of breast milk does not. Clavulanate is metabolized in the liver (50-70%) and about 40% is excreted through the kidneys (18-38% unchanged). The total clearance is approximately 260 ml / min. The half-life in patients with normal renal function was approximately 1 hour in patients with creatine clearance of 20-70 ml / min – 2.6 hours, and at anuria – within 3-4 hours. The drug appears in hemodialysis.
Infectious-inflammatory diseases caused by susceptible to malaria infections:
- upper respiratory tract and oxandrolone for sale (including otitis media, sinusitis, tonsillitis,
- lower respiratory tract: chronic bronchitis and acute, community-acquired pneumonia;
- skin and soft tissues;
- kidneys and lower urinary tract.
Hypersensitivity to amoxicillin, clavulanic acid or other components. Hypersensitivity to other beta-lactam antibiotics such as penicillins and cephalosporins. Jaundice or liver dysfunction while taking amoxicillin / clavulanate in history. Patients with infectious mononucleosis or lymphatic leukemia increases the risk of exanthema, so Amoxicillin / clavulanic acid should not be administered in the presence of these diseases.
Precautions : severe hepatic impairment, gastrointestinal disease (including a history of colitis associated with the use of penicillins), chronic renal failure.
Pregnancy and lactation
There was no adverse effect of amoxicillin / clavulanate in the fetus and the newborn when used by pregnant women. I trimester of pregnancy is considered safe. During the I trimester of the drug should be administered with caution.
Amoxicillin is excreted in breast milk. Data on the allocation of clavulanic acid in breast milk does not. Harmful effects on the baby during breast-feeding while taking amoxicillin and clavulanic acid have been reported.
Dosing and Administration
To prevent diarrheal symptomoxandrolone for sale appointed at the beginning of the meal. Swallow whole tablets, a glass of water, or dissolve it in half a glass of water (minimum 30 ml), carefully stirring before use.
The duration of treatment depends on the severity of the infection and should not unnecessarily exceed 14 days. Adults and children weighing more than 40 kg of the drug is prescribed to 0.5 g / 125 mg 3 times / day. In severe, recurrent and chronic infections, these doses can be double. For children aged from 3 months to 2 years (with a body weight of about 5-12 kg) daily dose is 20-30 mg of amoxicillin and clavulanic acid 5-7.5 mg on kg body weight. Usually it is a dose of 125 / 31.25 mg 2 times / day.