Following oral administration almost completely absorbed from the gastrointestinal tract. The “first pass” through the liver is metabolized to form various metabolites. When assigning oral dose of 100 mg of the time to reach maximum The main metabolites: metabolite and metabolite . The concentration of metabolites in blood plasma, respectively, 5 and 8 times higher than the concentration of the active substance. The half-life of pentoxifylline is from 0.4 to 0.8 hr .; oxandrolone dosage.
Write mainly kidneys as metabolites. Less than 4% of the dose is excreted in the feces. When assigning oral dose of 100 mg of the maximum concentration of basic substance and metabolites determined in 2-4 hours and is retained stable for a long period of time.
– peripheral circulatory disorders caused by atherosclerosis, diabetes (diabetic angiopathy);
– and atherosclerotic encephalopathy; angioneyropatii (paresthesia, Raynaud’s disease);
– trophic disorders of tissues as a result of violations of arterial or venous microcirculation (trophic ulcers, posttromboflebichesky syndrome, frostbite, gangrene);
– occlusive disease;
– subacute and chronic insufficiency of blood circulation in the retina or choroid;
– Violations hearing vascular genesis.
: Hypersensitivity to pentoxifylline and other methylxanthine derivatives; acute myocardial infarction; massive bleeding; nasal bleeding, acute hemorrhagic stroke, bleeding in the brain; massive bleeding in the retina of the eye; pregnancy, lactation, age 18 years (safety and efficacy in children has not been established).
Precautions: blood pressure lability, or with a tendency to arterial hypotension, congestive heart failure, atherosclerosis, cerebral and / or coronary vessels, peptic ulcer and 12 duodenal ulcer, the state after recently transferred surgical intervention, liver and / or kidney failure, severe arrhythmias , an increased tendency to bleeding, for example, by the use of anticoagulants or blood coagulation system disorders (risk of heavier bleeding).
Dosing and Administration
Inside, during a meal, not liquid, squeezed oxandrolone dosage small amounts of liquid. Set individually, taking into account the severity of circulatory disorders, the body weight of the patient and tolerability. Assign a dose of 100 mg 2-3 times a day. The maximum daily dose – 1200 mg. The duration of treatment – at least 8 weeks. In case of side effects dose should be reduced to 100 mg two times a day.
Patients with chronic renal failure (creatinine clearance less than 10 mL / min.) To designate 50-70% of normal dose.
Side effect From the digestive system: dry mouth, decreased appetite, nausea, vomiting, epigastric pain, diarrhea, intestinal atony; vascular bleeding from the stomach, intestines.
Cardio-vascular system: tachycardia, arrhythmia, false angina, the progression of symptoms of angina, lower blood pressure.
On the part of the central nervous system: headache, dizziness, anxiety, sleep disorders; convulsions.
Allergic reactions: skin rash, pruritus, urticaria, bleeding from vessels in the skin and mucous membranes, skin flushing, angioedema, anaphylactic shock.
Liver: cholecystitis, hepatitis, jaundice.
For the skin and subcutaneous fat: flushing of the face, “tides” of blood to the skin of the face and upper chest, swelling.
From the side of hematopoiesis and hemostasis system: thrombocytopenia, leukopenia, pancytopenia, gipofibrinogenemia; changes in oxandrolone dosage patterns of peripheral blood.