oxandrin

Allergic skin reactions: urticaria, erythematous rash, rarely – exudative erythema multiforme, rarely – exfoliative dermatitis, malignant exudative erythema , in some cases, there is the so-called “fifth day rash” . The reactions depend on the dose of the drug and the patient’s condition. The reactions of the digestive system: nausea, vomiting, diarrhea, abnormal liver function, increased activity of “liver” transaminases, in rare cases – cholestatic jaundice, hepatitis, pseudomembranous colitis. The increase in transaminases oxandrin, bilirubin and alkaline phosphatase is usually seen in males, and in elderly patients, especially those older than 65 years. To prevent adverse events is recommended to take the drug at the beginning of the meal. The risk of such changes is increased while taking the drug for more than 14 days. These phenomena are rarely observed in children. The above changes usually occur during or shortly after treatment. Sometimes it may appear several weeks after discontinuation of the drug. In general, the reaction on the part of the digestive system are transitory and minor character, but sometimes severe. Other: candidiasis, superinfection development, reversible increase of prothrombin time.

The following list shows, in descending order are the possible side effects: Most Gastrointestinal tract: nausea, vomiting, diarrhea, abdominal pain Immune reactions: urticaria Skin and soft tissue: rash RareBlood and lymphatic system: in the composition of the blood changes (leucopenia, thrombocytopenia, hemolytic anemia) Hepato-biliary system: cholestatic jaundice, hepatitis, immune system: angioedema, vasculitis, blood coagulation system: prolonged prothrombin time Mochevydelitelnaya system: interstitial nephritis Isolated cases of anaphylactic shock, angioedema, pseudomembranous colitis, erythema multiforme, exfoliative dermatitis

Overdose

Overdose can lead to gastrointestinal symptoms such as nausea, vomiting and diarrhea with the possible violation of water and electrolyte balance. Treatment Assign activated carbon. It is necessary to maintain the water and electrolyte balance. In convulsions diazepam prescribed. Other symptoms are treated symptomatically. In the case of severe renal insufficiency should be conducted hemodialysis.

Interaction with other drugs

Antacids, glucosamine, laxatives, drugs oxandrin, aminoglycosides slow down and reduce absorption; . ascorbic acid increases the absorption of
bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) -. antagonistic
Improves the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index). At the same time taking anticoagulants need to monitor the performance of blood clotting.
It reduces the effectiveness of oral contraceptives, medicines, in the process of metabolism that produce para-aminobenzoic acid, ethinyl estradiol – the risk of bleeding “breakthrough”.
Diuretics, allopurinol, phenylbutazone, nonsteroidal anti-inflammatory agents and other drugs, block tubular secretion, increase the concentration of amoxicillin (clavulanic acid is derived mainly by glomerular filtration).
Allopurinol increases the risk of skin rash.
amoxicillin should not be administered with disulfiram.
The simultaneous use of amoxicillin and digoxin may lead to increased digoxin plasma levels.

special instructions

In the treatment of penicillin in patients with hypersensitivity to it may experience an anaphylactic reaction. Treatment  in such cases should be immediately discontinued and replaced by other appropriate therapy. For the treatment of anaphylactic shock may require an emergency epinephrine, corticosteroids, and elimination of respiratory failure.
There is a possibility of cross-resistance and hypersensitivity to penicillins or other cephalosporins. As in the case of the other broad-spectrum penicillins may occur superinfections of fungal or bacterial origin (in particular – candidiasis), especially in patients with chronic diseases and / or disorders of the immune system function. In case of superinfection taking the drug overturned and / or pick up a suitable therapy.
In patients with impaired renal function the dose should be selected based on the severity of the condition.
Patients with impaired hepatic function of the combination of amoxicillin / clavulanic acid should be administered with caution and under constant medical supervision.  Should oxandrin not be used more than 14 days without the evaluation of liver function.
Occasionally there is an increase in prothrombin time. Amoxicillin / clavulanic acid should be administered with caution to patients receiving anticoagulant therapy.
Non-enzymatic methods for determining urinary sugar, as well as on the urobilinogen test can give false positive results.
In exchange treatment is necessary to monitor the state functions of blood, liver and kidneys.

oxandrolone for sale

The absolute bioavailability of amoxicillin is 94%. The absorption is independent of food intake. The maximum plasma concentration observed after 1-2 hours after administration of amoxicillin. After receiving a single dose of 500 / 125mg oxandrolone for sale, the average concentration of amoxicillin (after 8 hours) 0.3 mg / l. Binding to serum proteins is approximately 17-20%.

Amoxicillin crosses the placental barrier and passes into breast milk. Small amounts of Amoxicillin is metabolized in the liver (10% of the administered dose), mainly eliminated via the kidneys  and a small amount is excreted in the bile. The  of blood serum in patients with normal renal function was approximately 1 hr (0.9-1.2 hours) in patients with a creatinine clearance in the range of 10-30 ml / min is 6 hours, while in the case of anuria ranges between 10 and 15 hours. The drug appears in hemodialysis. Clavulanic acid: The absolute bioavailability of clavulanic acid of approximately 60%. The absorption is independent of food intake. The maximum concentration of clavulanic acid in the blood observed after 1-2 hours after administration. After a single dose of 0.5 g / 125 mg (amoxicillin / clavulanic acid) the mean maximum concentration of clavulanic acid reached 0.08 mg / l after 8 hours. Binding to plasma proteins is 22%. Clavulanic acid crosses the placental barrier. Reliable data on the penetration of breast milk does not. Clavulanate is metabolized in the liver (50-70%) and about 40% is excreted through the kidneys (18-38% unchanged). The total clearance is approximately 260 ml / min. The half-life in patients with normal renal function was approximately 1 hour in patients with creatine clearance of 20-70 ml / min – 2.6 hours, and at anuria – within 3-4 hours. The drug appears in hemodialysis.

Indications

Infectious-inflammatory diseases caused by susceptible to malaria infections:

 

  • upper respiratory tract and oxandrolone for sale (including otitis media, sinusitis, tonsillitis,
  • lower respiratory tract: chronic bronchitis and acute, community-acquired pneumonia;
  • skin and soft tissues;
  • kidneys and lower urinary tract.

Contraindications

Hypersensitivity to amoxicillin, clavulanic acid or other components. Hypersensitivity to other beta-lactam antibiotics such as penicillins and cephalosporins. Jaundice or liver dysfunction while taking amoxicillin / clavulanate in history. Patients with infectious mononucleosis or lymphatic leukemia increases the risk of exanthema, so Amoxicillin / clavulanic acid should not be administered in the presence of these diseases.

Precautions : severe hepatic impairment, gastrointestinal disease (including a history of colitis associated with the use of penicillins), chronic renal failure.

Pregnancy and lactation

There was no adverse effect of amoxicillin / clavulanate in the fetus and the newborn when used by pregnant women.  I trimester of pregnancy is considered safe. During the I trimester of the drug should be administered with caution.
Amoxicillin is excreted in breast milk. Data on the allocation of clavulanic acid in breast milk does not. Harmful effects on the baby during breast-feeding while taking amoxicillin and clavulanic acid have been reported.

Dosing and Administration

To prevent diarrheal symptomoxandrolone for sale appointed at the beginning of the meal. Swallow whole tablets, a glass of water, or dissolve it in half a glass of water (minimum 30 ml), carefully stirring before use.
The duration of treatment depends on the severity of the infection and should not unnecessarily exceed 14 days. Adults and children weighing more than 40 kg of the drug is prescribed to 0.5 g / 125 mg 3 times / day. In severe, recurrent and chronic infections, these doses can be double. For children aged from 3 months to 2 years (with a body weight of about 5-12 kg) daily dose is 20-30 mg of amoxicillin and clavulanic acid 5-7.5 mg on kg body weight. Usually it is a dose of 125 / 31.25 mg 2 times / day.

oxandrolone 10mg

Increase in activity of “liver” enzymes oxandrolone 10mg and alkaline phosphatase. Very rarely there are cases of aseptic meningitis. Rare: malaise, unpleasant taste in the mouth, salivation, conjunctivitis, scotoma, blurred vision, pain in the ear, increased fragility of nails, weight changes, swelling of the glands, nasal congestion;

Overdosing Symptoms: nausea, weakness, dizziness, tachycardia, decreased blood pressure, hyperthermia, drowsiness or agitation, loss of consciousness, areflexia, clonic-tonic convulsions, as a sign of gastrointestinal bleeding, vomiting like “coffee grounds”. Treatment: No specific antidote .

If after administration of the drug was not long, there should be gastric lavage (to prevent further absorption of the drug) and assign the activated carbon. In the case of vomiting with traces of blood gastric lavage is not allowed.

Conduct symptomatic therapy.

Interaction with other drugs
Pentoxifylline potentiates the anticoagulant effect of heparin, fibrinolytic agents, enhances the effect of antihypertensive and hypoglycemic agents (insulin and oral hypoglycemic agents).

Pentoxifylline may increase the effects of antibiotics (including cephalosporins -tsefamandola, tsefotetan), valproic acid.

Pentoxifylline cimetidine increases the concentration in plasma (the risk of side effects).

Co-administration with other xanthines can lead to excessive nervous excitement patients.

Cautions
Be careful when appointing oxandrolone 10mg patients with severe cerebral and / or coronary atherosclerosis, particularly with concomitant hypertension and cardiac arrhythmias. These patients may be angina, arrhythmias and hypotension.

With care should be prescribed to patients with gastric ulcer and duodenal ulcer (including history); patients who have recently undergone surgery (in these cases there is an increased risk of bleeding, so you need systematic monitoring of hemoglobin concentration and hematocrit).

In the case of the drug in patients with chronic heart failure previously to be achieved phase circulatory compensation. Patients with labile blood pressure, or with a tendency to hypotension dose increased gradually. Patients with severe renal impairment dose picked individually. In the case of simultaneous application Fleksitala and oral anticoagulants requires regular monitoring of the prothrombin time. In an application Fleksitala and antidiabetic or antihypertensive agents last dose of drugs should be reduced.

In case of bleeding in the retina of the eye during treatment  necessary to stop the drug immediately.

Drug treatment should be under oxandrolone 10mg the control of blood pressure. dose reduction may be required in elderly people (increased bioavailability and reduced clearance rate).

The safety and efficacy of pentoxifylline in children poorly understood.

Smoking may reduce the therapeutic efficacy of the drug.

oxandrolone dosage

Following oral administration almost completely absorbed from the gastrointestinal tract. The “first pass” through the liver is metabolized to form various metabolites. When assigning oral dose of 100 mg of the time to reach maximum  The main metabolites: metabolite and metabolite . The concentration of metabolites in blood plasma, respectively, 5 and 8 times higher than the concentration of the active substance. The half-life of pentoxifylline is from 0.4 to 0.8 hr .; oxandrolone dosage.

Write mainly kidneys as metabolites. Less than 4% of the dose is excreted in the feces. When assigning oral dose of 100 mg of the maximum concentration of basic substance and metabolites determined in 2-4 hours and is retained stable for a long period of time.

Indications
– peripheral circulatory disorders caused by atherosclerosis, diabetes (diabetic angiopathy);
– and atherosclerotic encephalopathy; angioneyropatii (paresthesia, Raynaud’s disease);
– trophic disorders of tissues as a result of violations of arterial or venous microcirculation (trophic ulcers, posttromboflebichesky syndrome, frostbite, gangrene);
– occlusive disease;
– subacute and chronic insufficiency of blood circulation in the retina or choroid;
– Violations hearing vascular genesis.

Contraindications
: Hypersensitivity to pentoxifylline and other methylxanthine derivatives; acute myocardial infarction; massive bleeding; nasal bleeding, acute hemorrhagic stroke, bleeding in the brain; massive bleeding in the retina of the eye; pregnancy, lactation, age 18 years (safety and efficacy in children has not been established).

Precautions: blood pressure lability, or with a tendency to arterial hypotension, congestive heart failure, atherosclerosis, cerebral and / or coronary vessels, peptic ulcer and 12 duodenal ulcer, the state after recently transferred surgical intervention, liver and / or kidney failure, severe arrhythmias , an increased tendency to bleeding, for example, by the use of anticoagulants or blood coagulation system disorders (risk of heavier bleeding).

Dosing and Administration
Inside, during a meal, not liquid, squeezed oxandrolone dosage small amounts of liquid. Set individually, taking into account the severity of circulatory disorders, the body weight of the patient and tolerability. Assign a dose of 100 mg 2-3 times a day. The maximum daily dose – 1200 mg. The duration of treatment – at least 8 weeks. In case of side effects dose should be reduced to 100 mg two times a day.

Patients with chronic renal failure (creatinine clearance less than 10 mL / min.) To designate 50-70% of normal dose.

Side effect From the digestive system: dry mouth, decreased appetite, nausea, vomiting, epigastric pain, diarrhea, intestinal atony; vascular bleeding from the stomach, intestines.

Cardio-vascular system: tachycardia, arrhythmia, false angina, the progression of symptoms of angina, lower blood pressure.

On the part of the central nervous system: headache, dizziness, anxiety, sleep disorders; convulsions.

Allergic reactions: skin rash, pruritus, urticaria, bleeding from vessels in the skin and mucous membranes, skin flushing, angioedema, anaphylactic shock.

Liver: cholecystitis, hepatitis, jaundice.

For the skin and subcutaneous fat: flushing of the face, “tides” of blood to the skin of the face and upper chest, swelling.

From the side of hematopoiesis and hemostasis system: thrombocytopenia, leukopenia, pancytopenia, gipofibrinogenemia; changes in oxandrolone dosage patterns of peripheral blood.

oxandrolone side effects

For the treatment of nosocomial infections caused , need combination therapy.
During treatment oxandrolone side effects should avoid direct sunlight and artificial  radiation (solarium), in order to avoid the development of photosensitivity reactions.
It should be in mind that patients with brain damage in history (stroke, severe head injury) may develop seizures, with insufficient glucose-6-phosphate dehydrogenase – the risk of hemolytic reaction.
since levofloxacin is excreted mainly by the kidneys, patients with impaired renal function requires control of renal function as well as correction of dosing regimen.
It was reported about lengthening  interval in patients receiving fluoroquinolones, including levofloxacin. When using fluoroquinolones, including levofloxacin, caution should be exercised in patients with known risk factors for prolongation of the interval : uncorrected violation of water-electrolyte imbalance (hypokalemia, hypomagnesemia); congenital  syndrome interval; heart disease (heart failure, myocardial infarction, bradycardia); concomitant use of drugs that can prolong  interval.
Elderly patients and female patients may be more sensitive to the drug, prolongs  interval. It should therefore be used with caution in these fluoroquinolones, including  .
In patients with diabetes mellitus who receive oral hypoglycemic agents (e.g. glibenclamide) or insulin, the application of levofloxacin increases the risk of hypo / hyperglycemia. Reported cases of hypoglycemic coma. In patients with diabetes need to monitor blood glucose.
In patients receiving fluoroquinolones, including levofloxacin, marked sensory and sensory-motor peripheral neuropathy, the beginning of which can be rapid. When the patient symptoms of neuropathy, the use of tablets oxandrolone side effects should be discontinued (to minimize possible risk of irreversible changes).  Should not be used in patients with gravis (myasthenia gravis).
When using quinolones, including levofloxacin, reported on the development of psychotic reactions, which in rare cases progressed to the development of suicidal thoughts and behavior disorders with self-harm (sometimes after receiving a single dose of levofloxacin). With the development of these reactions treatment ta should be discontinued and prescribe appropriate therapy. It should be used with caution to patients with psychosis or patients with a history of mental illness.
With the development of any impairment requires immediate consultation of the ophthalmologist.
Patients with severe community-acquired pneumonia caused by Streptococcus pneumoniae, tablets Fleksid ® can not provide the optimal therapeutic effect.
Levofloxacin may inhibit growth Mycobacterium tuberculosis, therefore, possible false-negative results of bacteriological tests for TB.
patients oxandrolone side effects , determination of opiates in urine may lead to false positive results, which should be acknowledged more specific methods.