6829

anavar half life

The drug is taken orally once or twice daily.  The tablets do not chew and drink plenty of fluids (0.5 to 1 cup), can be taken before meals or between meals. Doses oxandrolone anavar half life are determined by the nature and severity of the infection and the sensitivity of the alleged pathogen.

Patients with normal or moderately decreased kidney function, the recommended dose regimen of the drug:

Sinusitis (inflammation of the sinuses): 500 mg 1 time per day – 10 -14 days.

Exacerbation of chronic bronchitis: 250 mg or 500 mg 1 time per day -7-10 days.

Vnebolnichnaya pneumonia: 500 mg 1-2 times a day – 7-14 days.

Uncomplicated urinary tract infections: 250 mg 1 time per day – 3 days.

Prostatitis: 500 mg – 1 per day – 28 days.

Complicated urinary tract infections, including pyelonephritis: 250 mg 1 time per day – 7-10 days.

Infections of skin and soft tissues: 250 mg 1 time per day or 500 mg 1-2 times a day – 7-14 days.

Septicemia / bacteremia: 250 mg or 500 mg 1-2 times a day – 10-14 days.

Intra-abdominal infections: 250 mg or 500 mg 1 time per day – 7-14 days (in combination with antibacterial drugs acting on the anaerobic flora).

Skin reactions and general hypersensitivity reactions
sometimes itching and redness of the skin. Rare: general reactions of hypersensitivity (anaphylactic and anaphylactoid reaction) with symptoms such as urticaria, bronchoconstriction and possibly – heavy gasps. In very rare cases, – swelling of the skin and mucous membranes ( for example in the areas of the face and throat), sudden drop in blood pressure and shock; increased sensitivity to sunlight and ultraviolet radiation (see “Cautions.”); hypersensitivity pneumonitis; vasculitis. In some cases: severe rash with blistering, such as Stevens-Johnson syndrome, toxic epidermal necrolysis anavar half life and exudative erythema multiforme. General hypersensitivity reactions may sometimes be preceded by lighter skin reactions. The above-mentioned reaction may develop after the first dose in a few minutes or hours after administration.

 

Action on the gastrointestinal tract and metabolism Common: nausea, diarrhea. Sometimes: loss of appetite, vomiting, abdominal pain, dyspepsia. Rare: bloody diarrhea which in very rare cases, it may be a sign of bowel inflammation and even pseudomembranous colitis (see .. “Cautions”) Very rare: drop in blood sugar levels (hypoglycemia), which has particular importance for patients with diabetes; Possible symptoms of hypoglycemia: “wolf” appetite, nervousness, sweating, trembling. Experience with other quinolones suggests that they are capable of causing an exacerbation of porphyria (a very rare metabolic disease) in patients who are already suffering from the disease. Such an effect is not excluded when using levofloxacin formulation.

Nervous system Occasionally: headache, dizziness, and / or numbness, drowsiness, and sleep disorders. Rare: depression, anxiety, psychotic reactions (eg, hallucinations), discomfort (eg, paresthesias in the hands), tremor, psychotic reactions such as hallucinations and depression, restlessness, seizures, and mental confusion. Very rare: visual and hearing impairment, disturbances of taste and smell sensitivity, reduction of tactile sensitivity.

 

The action on the cardiovascular system Rare: increased heart rate, decreased blood pressure. Very rare: (shock-like) vascular collapse. In some cases: lengthening  interval.

 

Action on myshiy, tendons and bones Rare: defeat tendons (including tendonitis), joint and muscle pain. Very rare: tendon rupture (eg Achilles tendon); this side effect may occur within 48 hours after the start of treatment and may be bilateral in nature (see “Cautions.”); muscle weakness, which is of particular importance for patients with bulbar syndrome. In some cases: muscle damage (rhabdomyolysis).

 

Action on the liver and kidney Common: increase in anavar half life liver enzymes (eg, alanine aminotransferase and aspartate aminotransferase). Rare: increased levels of bilirubin and serum creatinine (sign of limitation of the liver or kidney). Very rare: hepatic reactions (eg, inflammation of the liver); deterioration of renal function until the acute renal failure, for example, due to allergic reactions (interstitial nephritis).

 

6832

anavar oxandrolone

A synthetic antibacterial agent of a broad spectrum fluoroquinolone, containing as active substance levofloxacin – laevorotatory isomer of ofloxacin.Levofloxacin blocking  gyrase, and crosslinking gives supercoiling breaks, inhibit anavar oxandrolone  synthesis, causes profound morphological change in the cytoplasm, the cell wall and membranes.
Levofloxacin is active against most strains of microorganisms in conditions in vitro and in vivo.

 

 

Levofloxacin is rapidly and almost completely absorbed after oral administration. Food intake has little effect on the speed and completeness of removals. Bioavailability of 500 mg oral levofloxacin after is nearly 100%. After administration of a single 500 mg dose of levofloxacin is the maximum concentration of 5.2-6.9 g / ml, time to maximum concentration -. 1,3ch half-life – 8.6 hours.

Relationship to plasma proteins – 30-40%. It penetrates the tissues and organs: lungs, bronchial mucosa, sputum, organs of the urogenital system, bone tissue, cerebrospinal fluid, the prostate gland, polymorphonuclear leukocytes, alveolar macrophages.

In the liver, a small part of the oxidized and / or deacetylated. Report from the body mainly by the kidneys by glomerular filtration and tubular secretion. Following anavar oxandrolone oral administration, approximately 87% of the dose is excreted in the urine unchanged within 48 hours, less than 4% in the faeces within 72 hours.

Indications for use:

Infectious-inflammatory diseases, caused by susceptible microorganisms: acute sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia, complicated urinary tract infections (including pyelonephritis), uncomplicated urinary tract infections, prostatitis, infections of skin and soft tissues, septicemia / bacteremia associated with the above readings, intra-abdominal infection.

Contraindications

  • hypersensitivity to levofloxacin or other quinolones;
  • epilepsy;
  • tendon injury during the earlier treatment of quinolones;
  • childhood and adolescence (18 years);
  • pregnancy and lactation.

Carefully

The drug should be used with caution in the elderly, due to the high probability of the presence of a concomitant decrease in renal function, with a deficit of anavar oxandrolone dehydrogenase.

6834

anavar pills

For topical administration the therapeutic concentration of drug achieved in the eye tissues. Infectious-inflammatory diseases of the anterior eye, caused anavar pills by susceptible microorganisms to ofloxacin, blepharitis, barley, conjunctivitis, dacryocystitis, keratitis, corneal ulcer, chlamydial eye infection, prevention and treatment of bacterial infection after eye injuries and surgeries.

Contraindications :

Hypersensitivity to the drug, pregnancy, lactation.

Dosage and administration :

Drops
drug instilled 1 drop in the conjunctival sac of the patient’s eyes 2-4 times a day, is not recommended to use the drug for more than 2 weeks.
With the simultaneous use of more than one drug is necessary to observe a minimum of 5-minute interval between installations. Ointment 1.5 cm strip of ointment is pawned for the lower eyelid of the patient’s eyes 2-3 times a day, in the case of Chlamydia infection – 5 times a day, is not recommended to use the drug for more than 2 weeks. Perhaps a combination of eye anavar pills drops and ointments Floksal.With simultaneous use of more than one drug ointment should be used last.

Use during pregnancy and lactation :

No information about the harmful effects of ofloxacin on the fetus, but not rekomendetsya use the drug during pregnancy and lactation.

Side effects :

Allergic reactions; transient conjunctival hyperemia, burning sensation; discomfort in the eyes, itching and dryness of the conjunctiva, photophobia, lacrimation, rarely – dizziness.

Interaction with other drugs :

Drug interactions of the drug has not been described.

Special instructions :

Do not wear contact lenses while using the drug. Wear sunglasses (because of the possible development of photophobia) and avoid prolonged exposure to bright light.
After applying the ointment temporarily reduced visual acuity, it is necessary to take into account when driving or operating machinery.

Product form :

0.3% eye drops in bottles of 5 ml; 0.3% eye ointment in tubes, 3 g in a carton box with instruction on the medical application.

Storage conditions :

In the dark, at a temperature no higher anavar pills than 25 ° C and out of reach of children.